Bioavailable gluconate chelated stannous fluoride toothpaste meta-analyses: Effects on dentine hypersensitivity and enamel erosion

To compare the effect of bioavailable gluconate-chelated stannous fluoride (SnF2) toothpaste with control toothpastes for treatment dentine hypersensitivity (DH) and enamel erosion. A Procter & Gamble Oral Care archive clinical studies was reviewed from 2000 to 2020. Eligible were Randomised Controlled Trials (RCTs) investigating SnF2 efficacy compared controls in adult participants measured following tactile (Yeaple force) and/or evaporative stimuli (Schiff score) in-vivo, duration <2 months (DH); or by erosive toothwear (profilometry) in-situ samples, 10–15 days. Two authors independently assessed eligibility resolved disagreements discussion. meta-analysis undertaken Risk Bias (RoB) using Cochrane collaboration RoB tool randomized parallel-group cross-over trials. Fourteen RCTs (1287 participants) DH relief Six (184 erosion protection. For provided a 57 % (evaporative air) 142 (tactile) benefit versus negative (sodium fluoride/monofluorophosphate, 8 studies; p < 0.001). Compared positive (potassium nitrate arginine, 6 studies), 22 advantage (p = 0.036) seen air. In studies, an 83 (arginine sodium fluoride; 0.001) change (95 %CI) average surface profilometry level (?m) -2.02(-2.85, -1.20). The use these toothpastes, as part daily oral hygiene regimen, will provide patients protection, combined alleviation pain when present, improving quality life.